The present physics understandings of magnetohydrodynamic (MHD) stability o
f tokamak plasmas, the threshold conditions for onset of MHD instability, a
nd the resulting operational limits on attainable plasma pressure (beta lim
it) and density (density limit), and the consequences of plasma disruption
and disruption related effects are reviewed and assessed in the context of
their application to a future DT burning reactor prototype tokamak experime
nt such as ITER. The principal considerations covered within the MHD stabil
ity and beta limit assessments are (i) magnetostatic equilibrium, ideal MHD
stability and the resulting ideal MHD beta limit; (ii) sawtooth oscillatio
ns and the coupling of sawtooth activity to other types of MHD instability;
(iii) neoclassical island resistive tearing modes and the corresponding li
mits on beta and energy confinement; (iv) wall stabilization of ideal MHD i
nstabilities and resistive wall instabilities; (v) mode locking effects of
non-axisymmetric error fields; (vi) edge localized MHD instabilities (ELMs,
etc.); and (vii) MHD instabilities and beta/pressure gradient limits in pl
asmas with actively modified current and magnetic shear profiles. The princ
ipal considerations covered within the density limit assessments are (i) em
pirical density limits; (ii) edge power balance/radiative density limits in
ohmic and L-mode plasmas; and (iii) edge parameter related density limits
in H-mode plasmas. The principal considerations covered in the disruption a
ssessments are (i) disruption causes, frequency and MHD instability onset;
(ii) disruption thermal and current quench characteristics; (iii) vertical
instabilities (VDEs), both before and after disruption, and plasma and in-v
essel halo currents, (iv) after disruption runaway electron formation, conf
inement and loss; (v) fast plasma shutdown (rapid externally initiated diss
ipation of plasma thermal and magnetic energies); (vi) means for disruption
avoidance and disruption effect mitigation and (vii) 'integrated' modellin
g of disruptions and fast shutdown and of the ensuing effects. In each inst
ance, the presentation within a given topical area progresses from a summar
y of present experimental and theoretical understanding to how this underst
anding projects or extrapolates to an ITER class reactor regime tokamak. Ex
amples of extrapolations to the specific ITER design concept developed duri
ng the course of the ITER EDA are given, and assessments of the degree of a
dequacy of present understanding are also provided. In areas where present
understanding is identified to be less than fully adequate, areas in which
continuing or new research is needed are identified.