The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000

SWISS-PROT is a curated protein sequence database which:strives to provide a high level of annotation (such as the description of the function of a pr otein, its domains structure, post-translational modifications, variants, e tc.), a minimal level of redundancy and high level of integration with othe r databases, Recent developments of the database include format and content enhancements, cross-references to additional databases, new documentation files and improvements:to TrEMBL, a computer-annotated supplement to SWISS- PROT. TrEMBL consists of entries in SWISS-PROT-like format derived from the translation of all coding sequences (CDSs) in the EMBL Nucleotide Sequence Database, except the CDSs already included in SWISS-PROT. We also describe the Human Proteomics Initiative (HPI), a major project to annotate all kno wn human sequences according to the quality standards of SWISS-PROT, SWISS- PROT is available at: http://www.expasy.ch/sprot/ and http://www.ebi.ac.uk/ swissprot/.