XREFdb supports the investigation of protein function in the context of inf
ormation available through work in multiple organisms. In addition to facil
itating the association of functional data among known genes from multiple
organisms, XREFdb has developed strategies that provide access to informati
on associated with as-yet unstudied genes. The database organizes protein s
imilarity and genetic map positional information from diverse sources in th
e public domain to facilitate investigator evaluation of potential function
al significance. XREFdb is found at URL www.ncbi.nlm.nih. gov/XREFdb.