SRPDB (Signal Recognition Particle Database)

The signal recognition particle database (SRPDB) is maintained at the Unive rsity of Texas Health Science Center at Tyler, Texas, and organizes SRP-rel ated information about SRP RNA, SRP proteins and the SRP receptor, SRPDB is accessible on the WWW at the URL http://psyche.uthct.edu/dbs/SRPDB/SRPDB.h tml. A mirror site of the SRPDB is located in Europe at the University of G oteborg, Sweden (http://www.medkem. gu.se/dbs/SRPDB/SRPDB.html), This relea se of SRPDB adds 10 new SRP RNA sequences (a total of 117 SRP RNAs), four p rotein SRP19 sequences (a total of 15), seven-new SRP54 (ffh) sequences (a total of 52), and eight sequences of the SRP receptor alpha subunit (FtsY) (total of 36), Sequences are arranged in alphabetical:and phylogenetic orde r and alignments are provided which highlight base paired and conserved reg ions. SPRDB also provides motifs to find new sequences, a brief introductio n to SRP function in protein secretion, numerous SRP RNA secondary structur e diagrams, 3-D SRP RNA models, and recently obtained crystal structure PDB coordinates of the human SRP54m domain.