The Eukaryotic Promoter Database (EPD)

The Eukaryotic Promoter Database (EPD) is an annotated non-redundant collec tion of eukaryotic POL II promoters for which the transcription start site has been determined experimentally. Access to promoter sequences is provide d by pointers to positions in nucleotide sequence entries. The annotation p art of an entry includes a description of the initiation site mapping data, exhaustive cross-references to the EMBL nucleotide sequence database, SWIS S-PROT, TRANSFAC and other databases, as well as bibliographic references, EPD is structured in a way that facilitates dynamic extraction of biologica lly meaningful promoter subsets for comparative sequence analysis, WWW-base d interfaces have been developed that enable the user to view EPD entries i n different formats, to select and extract promoter sequences according to a variety of criteria, and to navigate to related databases exploiting diff erent cross-references. The EPD web site also features yearly updated base frequency matrices for major eukaryotic promoter elements, EPD can be acces sed at http://www.epd.isb-sib.ch.