HUGE: a database for human large proteins identified in the Kazusa cDNA sequencing project

HUGE is a database for human large proteins newly identified in the Kazusa cDNA project, the aim of which is to predict the primary structure of prote ins from the sequences of human large cDNAs (>4 kb). In particular, cDNA cl ones capable of coding for large proteins (>50 kDa) are the current targets of the project. HUGE contains >1100 cDNA sequences and detailed informatio n obtained through analysis of the sequences of cDNAs and the predicted pro teins, Besides an increase in the number of cDNA entries, the amount of exp erimental data for expression profiling has been largely increased and data on chromosomal locations have been newly added, All of the protein-coding regions were examined by GeneMark analysis, and the results of a motif/doma in search of each predicted protein sequence against the Pfam database have been newly added. HUGE is available through the WWW at http://www.kazusa.o r.jp/huge.