Human immunodeficiency virus reverse transcriptase and protease sequence database

The HIV RT and Protease Sequence Database is an online relational database that catalogs evolutionary and drug-related human immunodeficiency virus (H IV) reverse transcriptase (RT) and protease sequence variation (http://hivd b.stanford.edu), The database contains a compilation of nearly all publishe d HIV RT and protease sequences including International Collaboration datab ase submissions (e.g., GenBank) and sequences published in journal articles , Sequences are linked to data about the source of the sequence sample and the antiretroviral drug treatment history of the individual from whom the i solate was obtained, The database is curated and sequences are annotated wi th data from >230 literature references. Users can retrieve additional data and view alignments of sequence sets meeting specific criteria (e.g,, trea tment history, subtype, presence of a particular mutation), A gene-specific sequence analysis program, new user-defined queries and nearly 2000 additi onal sequences were added in 1999.