KinMutBase, a database of human disease-causing protein kinase mutations

KinMutBase (http://www.uta.fi/imt/bioinfo/KinMutBase/) is a registry of mut ations in human protein kinases related to-disorders. Kinases are essential cellular signaling molecules, in which mutations can lead to diseases, inc luding immunodeficiencies, cancers and endocrine disorders, The first relea se of KinMutBase contained information for protein tyrosine kinases. The cu rrent release includes also serine/threonine protein kinases, as well as an update of the tyrosine kinases, There are 251 entries altogether, represen ting 337 families and 621 patients. Mutations appear both in conserved hall mark residues of the kinases as well as in non-homologous sites. The KinMut Base WWW pages provide plenty of information, namely mutation statistics la nd display, clickable sequences with mutations and changes to restriction e nzyme patterns.