ras gene mutations in oral cancer in eastern India

Oral tumor specimens (n = 50) from eastern Indian population were studied f or the presence of mutations in the H-, K- and N-ras genes using selective oligodeoxynucleotide hybridization and restriction fragment length polymorp hism analysis of polymerase chain reaction-amplified products. Mutations in H- and K-ras genes were observed at a frequency of 28 and 33%, respectivel y, whereas no N-ras mutation was noticed. (C) 2000 Published by Elsevier Sc ience Ltd. All rights reserved.