LPS INJECTED INTO THE PREGNANT RAT LATE IN GESTATION DOES NOT INDUCE FETAL ENDOTOXEMIA

Authors
GOTO M YOSHIOKA T RAVINDRANATH T BATTELINO T YOUNG RI ZELLER WP
Citation
M. Goto et al., LPS INJECTED INTO THE PREGNANT RAT LATE IN GESTATION DOES NOT INDUCE FETAL ENDOTOXEMIA, Research communications in molecular pathology and pharmacology, 85(1), 1994, pp. 109-112
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Pathology
Journal title
Research communications in molecular pathology and pharmacology → ACNP
ISSN journal
10780297
Volume
85
Issue
1
Year of publication
1994
Pages
109 - 112
Database
ISI
SICI code
1078-0297(1994)85:1<109:LIITPR>2.0.ZU;2-T
Abstract
Endotoxin is abortifacient. Abortion may be due to maternal, fetal or combined endotoxemia. The present study was performed to evaluate if f etal rat endotoxemia was induced by maternal endotoxemia in late gesta tion. An intraperitoneal injection of smooth lipopolysaccharide (Esche richia coli LPS and Shigella flexneri LPS) or rough LPS (Rc mutant Esc herichia coli LPS) induced Limulus activity in maternal plasma, but no t fetal plasma. These results suggest that fetal rat endotoxemia is no t induced during maternal endotoxemia. Thus, the abortion may not be d ue to fetal endotoxemia.