Synthesis of some N-substituted 3,4-pyrroledicarboximides as potential CNSdepressive agents

Authors
Malinka, W Sieklucka-Dziuba, M Rajtar, G Rejdak, R Rejdak, K Kleinrok, Z
Citation
W. Malinka et al., Synthesis of some N-substituted 3,4-pyrroledicarboximides as potential CNSdepressive agents, PHARMAZIE, 55(1), 2000, pp. 9-16
Citations number
22
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMAZIE
ISSN journal
00317144 → ACNP
Volume
55
Issue
1
Year of publication
2000
Pages
9 - 16
Database
ISI
SICI code
0031-7144(200001)55:1<9:SOSN3A>2.0.ZU;2-F
Abstract
As a continuation of our work on N-[4-aryl(heteroaryl)piperazin-1-ylalkyl]- 3,4-pyrroledicarboximides, which were characterized by strong analgesic act ivity and CNS depressive action, several novel N-substituted 3,4-pyrroledic arboximides were prepared and eleven representatives were examined in a ser ies of in vivo CNS tests, A few of these compounds displayed a similar prof ile of biological selectivity to that of 3,4-pyrroledicarboximides describe d previously; their structure-activity relationships are discussed.