In the context of inflationary models with a pre-inflationary stage, in whi
ch the Einstein equations are obeyed, the null energy condition is satisfie
d, and spacetime topology is trivial, we argue that homogeneity on super-Hu
bble scales must be assumed as an initial condition, Models in which inflat
ion arises from field dynamics in a Friedmann-Robertson-Walker background f
all into this class but models in which inflation originates at the Planck
epoch may evade this conclusion. Our arguments rest on causality and genera
l relativistic constraints on the structure of spacetime. We discuss modifi
cations to existing scenarios that may avoid the need for initial large-sca
le homogeneity.