We investigate higher dimensional cosmological models in the semiclassical
approximation with Hartle-Hawking boundary conditions, assuming a gravitati
onal action which is described by the scalar curvature with a cosmological
constant. In the framework the probability for quantum creation of an infla
tionary universe with a pair of black holes in a multidimensional universe
is evaluated. The probability for creation of a universe with a spatial sec
tion with (SXSD-2)-X-1 topology is then compared with that of a higher dime
nsional de Sitter universe with SD-1 spatial topology. It is found that a h
igher dimensional universe with a product space with a primordial black hol
es pair is less probable to nucleate when the extra dimensions scale factor
s do not vary in an inflating universe.