The study of inhibition of DNA synthesis by hydroxyurea(s)

Authors
Agrawal, VK Bano, S Mathur, KC Khadikar, PV Karmarkar, S Mandloi, M Sapre, NS
Citation
Vk. Agrawal et al., The study of inhibition of DNA synthesis by hydroxyurea(s), P I A S-CH, 111(6), 1999, pp. 697-708
Citations number
20
Categorie Soggetti
Chemistry
Journal title
PROCEEDINGS OF THE INDIAN ACADEMY OF SCIENCES-CHEMICAL SCIENCES
ISSN journal
02534134 → ACNP
Volume
111
Issue
6
Year of publication
1999
Pages
697 - 708
Database
ISI
SICI code
0253-4134(199912)111:6<697:TSOIOD>2.0.ZU;2-0
Abstract
A novel method for the study of inhibition of DNA synthesis by hydroxyurea( s) using topological indices and frontier molecular orbital energies: E-hor mo, E-lumo, and E-total is described. The data suggest that the inhibitory activities of urea(s) can be successfully modelled by these molecular descr iptors. Excellent results are obtained in multivariate systems as well as u pon introducing a dummy parameter.