The purpose of this study was to determine whether Gulf War Illness (GWI) c
an be explained by the presence of psychiatric disorders as assessed by DSM
-III-R, To reduce the heterogeneity amongst Persian Gulf War veterans with
GWI (PGV-F), only those were studied who presented with severe fatigue as a
major complaint and also fulfilled clinical case definitions for Chronic F
atigue Syndrome, Idiopathic Chronic Fatigue, and/or Multiple Chemical Sensi
tivity. A total of 95 Registry PGVs were examined; 53 presented with GWI an
d 42 did not report any post-war health problems (PGV-H). All subjects were
assessed for the presence of DSM-III-R Axis I psychiatric disorders. Compa
red to PGV-Hs, 49% of PGV-Fs had similar post-war psychiatric profiles: eit
her no, or only one, psychiatric disorder was diagnosed. Psychiatric profil
es of the remaining 51% of PGV-Fs were significantly different from PGV-Hs
in that most of these veterans suffered from multiple post-war psychiatric
diagnoses. The presence of psychiatric disorders as assessed by DSM-III-R c
riteria cannot explain symptoms of Gulf War Illness among all Persian Gulf
veterans with severe fatiguing illness. (C) 1999 Elsevier Science Ireland L
td. All rights reserved.