Remodeling of the endocrine pancreas: The central role of amylin and insulin resistance

Background. Remodeling of the endocrine pancreas, caused by the deleterious effects of amylin as it is co-synthesized, co-packaged, and co-secreted wi th insulin, gives clinicians and researchers cause to ponder. Methods, A literature search was done, and relevant publications and texts on amylin and islet amyloid polypeptide (IAPP) were reviewed. Results, The mechanisms and clinical consequences attributed to the remodel ing of the endocrine pancreas, along with proposals for reevaluating the me thods of treating patients who have type 2 diabetes are illustrated and dis cussed. Conclusions, In addition to controlling the devastating effects of glucotox icity, lipotoxicity and hypertension, we should consider the newer hypoglyc emic agents with regard to their effects on the remodeling of the endocrine pancreas. This remodeling results in structural and subsequent functional changes, causing continued elevations of hemoglobin A(IG). Studies are indi cated to determine whether amylin (IAPP) may be implicated in the remodelin g of the arterial vessel wall, the glomerulus of the kidney, and the cardia c interstitium.