A transitional model of barrier methods compliance with unbalanced loss tofollow-up

Citation
Pl. Chen et al., A transitional model of barrier methods compliance with unbalanced loss tofollow-up, STAT MED, 19(1), 2000, pp. 71-82
Citations number
16
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
STATISTICS IN MEDICINE
ISSN journal
02776715 → ACNP
Volume
19
Issue
1
Year of publication
2000
Pages
71 - 82
Database
ISI
SICI code
0277-6715(20000115)19:1<71:ATMOBM>2.0.ZU;2-O
Abstract
Differential loss to follow-up can substantially influence the evaluation o f treatment effects on a dichotomous outcome of interest in longitudinal tr ials. The use of transitional models incorporating loss to follow-up as an additional category of response and the nature of the correlated responses can provide a comprehensive view of a trial with unbalanced loss to follow- up. Under the Markov assumption, transitional models estimate the probabili ty of changing from one outcome to another outcome between follow-up visits . Patterns of the response variable can be described by the estimated trans ition probabilities. The effects of intervention and covariates on the outc ome of interest can also be estimated using a conditional likelihood functi on or a multinomial legit regression. Data from a randomized barrier method study designed to compare the proportion of participants using barrier met hods consistently in two counselling groups are used to illustrate the prop osed model. Copyright (C) 2000 John Wiley & Sons, Ltd.