EXPANDED-BED ADSORPTION IN INDUSTRIAL BIOPROCESSING - RECENT DEVELOPMENTS

Expanded-bed adsorption allows the capture of proteins from particle-c ontaining feedstocks without prior removal of particulates, thus enabl ing clarification of a cell suspension or cell homogenate and the conc entration of the desired product in a single operation. This usually r esults in higher product recovery in a shorter time period,Process dev elopment and scale-up of an expanded-bed operation is convenient becau se both the adsorbent and the equipment are similar to those in conven tional packed-bed chromatography. This article reviews the recent deve lopments in expanded-bed adsorption technology and the range of applic ations that are now being achieved.