Sequences of yne-ene cross metathesis and Diels-Alder cycloaddition reactions - Modular solid phase synthesis of substituted octahydrobenzazepinones

Reaction sequences involving yne-ene cross metathesis and Diels-Alder cyclo addition reactions in solution and on solid support provide rapid access to cyclic cores incorporating variable side chains. A combinatorial approach to substituted octahydrobenzo[c]azepin-3-ones has been developed applying t his chemistry in connection with a cyclization/cleavage strategy that gives rise to products of high purity.