BINOL-Ti-catalyzed carbonyl-ene cyclization by tuning the 6-Br-ligand for the synthesis of 2-methyl-19-nor-22-oxa vitamin D analogue with significantdifferentiation activity

Authors
Mikami, K Koizumi, Y Osawa, A Terada, M Takayama, H Nakagawa, K Okano, T
Citation
K. Mikami et al., BINOL-Ti-catalyzed carbonyl-ene cyclization by tuning the 6-Br-ligand for the synthesis of 2-methyl-19-nor-22-oxa vitamin D analogue with significantdifferentiation activity, SYNLETT, (12), 1999, pp. 1899-1902
Citations number
55
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
12
Year of publication
1999
Pages
1899 - 1902
Database
ISI
SICI code
0936-5214(199912):12<1899:BCCBTT>2.0.ZU;2-S
Abstract
Transition state control in BINOL-Ti-catalyzed asymmetric carbonyl-ene cycl ization by tuning the 6-Br-BINOL ligand completes the synthesis of the A ri ng of the 2-methyl-19-nor-22-oxa D-3 analogue (2), which shows the signific ant activity in differentiation of HL-60 cell.