A convenient method for the N-acylation and esterification of hindered amino acids: Synthesis of ultra short acting opioid agonist, remifentanil

Authors
Coleman, MJ Goodyear, MD Latham, DWS Whitehead, AJ
Citation
Mj. Coleman et al., A convenient method for the N-acylation and esterification of hindered amino acids: Synthesis of ultra short acting opioid agonist, remifentanil, SYNLETT, (12), 1999, pp. 1923-1924
Citations number
8
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
12
Year of publication
1999
Pages
1923 - 1924
Database
ISI
SICI code
0936-5214(199912):12<1923:ACMFTN>2.0.ZU;2-E
Abstract
A general method has been devised for the one step preparation of N-acylami no acid esters of type 7 from the corresponding alpha-amino acids in high y ield under mild conditions and a probable mechanism is proposed.