A concise synthesis of N-(trideuteromethyl)morpholine-N-oxide monohydrate

Authors
Rosenau, T Potthast, A Kosma, P
Citation
T. Rosenau et al., A concise synthesis of N-(trideuteromethyl)morpholine-N-oxide monohydrate, SYNLETT, (12), 1999, pp. 1972-1974
Citations number
16
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
12
Year of publication
1999
Pages
1972 - 1974
Database
ISI
SICI code
0936-5214(199912):12<1972:ACSONM>2.0.ZU;2-D
Abstract
An efficient synthesis of N-(trideuteromethyl)morpholine-N-oxide monohydrat e (3) is described. The procedure applies the tocopheryl protecting group, and makes use of sodium percarbonate as the oxidant and water donor, thus a voiding both the troublesome direct alkylation of morpholine and the unsuit able oxidation by aqueous hydrogen peroxide. Overall yields of purified mat erial range above 90%.