Y. Nakamura et al., Preparation of a fluorous chiral BINOL derivative and application to an asymmetric protonation reaction, TETRAHEDRON, 56(3), 2000, pp. 351-356
Fluorous Chiral Proton Source (R,S)-FDHPEB resulted in a higher enantiosele
ctivity (95% ee) than that of the original nonfluorous (R,S)-DHPEB (87% ee)
in an enantioselective protonation of a samarium enolate. (R,S)-FDHPEB was
easily recovered by a simple filtration through a fluorous reverse phase s
ilica gel and was recyclable. (C) 2000 Elsevier Science Ltd. All rights res
erved.