New chiral ligands derived from (S)-leucine for the enantioselective addition of diethylzinc to aldehydes

Authors
Kawanami, Y Mitsuie, T Miki, M Sakamoto, T Nishitani, K
Citation
Y. Kawanami et al., New chiral ligands derived from (S)-leucine for the enantioselective addition of diethylzinc to aldehydes, TETRAHEDRON, 56(2), 2000, pp. 175-178
Citations number
21
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
56
Issue
2
Year of publication
2000
Pages
175 - 178
Database
ISI
SICI code
0040-4020(20000107)56:2<175:NCLDF(>2.0.ZU;2-L
Abstract
A new series of chiral beta-amino alcohols derived from (S)-leucine has bee n synthesized. The amino alcohol possessing a piperidine ring and a pheneth yl group on the carbinol carbon atom was found to be an efficient ligand to catalyze the enantioselective addition of diethylzinc to aromatic (up to 9 7% ee) and aliphatic (up to 95% ee) aldehydes. (C) 1999 Elsevier Science Lt d. All rights reserved.