Synthesis of new glycosylated neutral and cationic porphyrin dimers

Authors
Kaldapa, C Blais, JC Carre, V Granet, R Sol, V Guilloton, M Spiro, M Krausz, P
Citation
C. Kaldapa et al., Synthesis of new glycosylated neutral and cationic porphyrin dimers, TETRAHEDR L, 41(3), 2000, pp. 331-335
Citations number
24
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
3
Year of publication
2000
Pages
331 - 335
Database
ISI
SICI code
0040-4039(20000115)41:3<331:SONGNA>2.0.ZU;2-G
Abstract
The synthesis and characterisation of symmetrical glycosylated neutral and cationic porphyrin dimers linked at the meso-position via a flexible hydroc arbon chain to improve targeting on malignant cells is reported. Photocytot oxicity of these compounds against the K562 leukemia cell line compared to the effect of hematoporphyrin is also presented. (C) 2000 Elsevier Science Ltd. All rights reserved.