Citation
J. Canotilho et al., Enthalpy of solution of terfenadine in ethanol/water mixtures, THERMOC ACT, 344(1-2), 2000, pp. 9-13
Citations number
14
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
THERMOCHIMICA ACTA
ISSN journal
00406031
→ ACNP
Volume
344
Issue
1-2
Year of publication
2000
Pages
9 - 13
Database
ISI
SICI code
0040-6031(20000128)344:1-2<9:EOSOTI>2.0.ZU;2-L
Abstract
The enthalpy of solution of terfenadine in ethanol/water mixtures, 0-20.5 w
t.% of water was determined by calorimetry. A Sudden increase of 1-2 kJ mol
(-1) in the enthalpy at a concentration value around 0.01 mol kg(-1) is obs
erved. This step in the enthalpy is interpreted as due to solute n-mer aggr
egates formation. The solubility of terfenadine in the cosolvent systems us
ed in the calorimetric studies was determined. (C) 2000 Elsevier Science B.
V. All rights reserved.