Factor II G20210A and factor V G1691A gene mutations and peripheral arterial occlusive disease

Background. G to A mutations at positions 20210 of the prothrombin gene (F2 ) and 1691 of the factor V gene (F5) are established risk factors for venou s thrombosis. Several factors associated with coagulation and/or fibrinolys is have been associated with arterial occlusive disease, but the role of F2 20210A and F5 1691A for arterial occlusive disease remains unclear. Object ive. To investigate if F2 20210A and F5 1691A are associated with periphera l arterial occlusive disease (PAOD). Methods and Results. We analyzed the p revalence of F2 20210A and F5 1691A alleles in 336 patients with documented PAOD at Fontaine stage LI - IV and 300 controls without vascular disease. Allele frequencies in patient!, and controls were 0.013 and 0.022 for F2 20 210A, and 0.042 and 0.045 for F5 1691, respectively, both differences being not statistically significant. Conclusion. Our data suggest that mutations F2 G20210A and F5 G1691A are not associated with PAOD.