Restorative effects of zinc and selenium on nitrergic relaxations impairedby cadmium in the mouse corpus cavernosum

Citation
C. Gocmen et al., Restorative effects of zinc and selenium on nitrergic relaxations impairedby cadmium in the mouse corpus cavernosum, TOX LETT, 111(3), 2000, pp. 229-234
Citations number
28
Categorie Soggetti
Pharmacology & Toxicology
Journal title
TOXICOLOGY LETTERS
ISSN journal
03784274 → ACNP
Volume
111
Issue
3
Year of publication
2000
Pages
229 - 234
Database
ISI
SICI code
0378-4274(20000105)111:3<229:REOZAS>2.0.ZU;2-A
Abstract
We investigated whether Cd2+ intake (in drinking water, 15 ppm) for 30 days can affect the nitrergic relaxations of the mouse corpus cavernosum (CC) a nd whether Zn2+ (25 mg kg(-1) via a stomach tube at 48-h intervals) or sodi um selenate (8 mu g kg(-1) day(-1) intraperitoneally) has a restorative act ion on the impairment in the response. Relaxant responses of the CC obtaine d from Cd2+-treated mice to electrical field stimulation (neurogenic) or ac etylcholine (endothelium dependent) were significantly inhibited. A partial restoration was observed in the nitrergic relaxation of the CC obtained fr om Zn2+- or sodium selenate-co-treated animals. Neither agent exhibited any significant action on the responses of the tissue from control mice. There was no significant difference between Cd2+-treated and control mice in res pect of the relaxation amplitude induced by sodium nitroprusside or papaver ine. These results suggest that Cd2+ intake may impair the nitrergic relaxa tion of the mouse CC, and, co-treatment with Zn2+ or sodium selenate may pa rtially improve the nitrergic mechanisms in the tissue. (C) 2000 Elsevier S cience Ireland Ltd. All rights reserved.