Global brain ischemia produced by clamping left subclavian artery and bicarotid trunk in the rabbit

Thirty-five rabbits were divided randomly into 5 groups: sham operation, 10 minutes clamping bicarotid trunk (partial ischemia, PI), and 3 groups of 5 , 7, and 10 minutes clamping left subclavian artery and bicarotid trunk (gl obal ischemia, GI). Systolic arterial pressure increased slightly in the PI group, but doubled in the GI groups during clamping. Heart rate did not ch ange in the PI group, but decreased transiently in the GI groups during cla mping. Brain temperature decreased gradually in the GI groups during clampi ng, but did not change in the PI group. Necrotic changes were present 96 ho urs later in approximately 50% of the hippocampal CA1 cells in the GI group s, but in none of the cells in the PI and sham operation groups, The presen t results may indicate that clamping left subclavian artery and bicarotid t runk in the rabbit brings about global brain ischemia. Copyright (C) 2000 b y W.B. Saunders Company.