COMBINED EFFECTS OF LIPOPROTEIN-LIPASE AND APOLIPOPROTEIN-E POLYMORPHISMS ON LIPID AND LIPOPROTEIN LEVELS IN THE STANISLAS COHORT

We have genotyped 1101 supposedly healthy subjects from the Stanislas cohort for the lipoprotein lipase (LPL) gene Ser(447)(C) --> stop (G) Polymorphism and/or for the apolipoprotein (apo)E common polymorphism. Genotypic effects of the two polymorphisms on fasting serum triglycer ides (TG), total cholesterol (Tchol), high density lipoprotein-cholest erol (HDLc), low density lipoprotein-cholesterol (LDLc), apoB, apoA-I, and apoE levels were studied separately for each polymorphism and in conjunction. epsilon 4 allele and high apoE levels were associated wit h high levels of LDLc, Tchol, apoB, and TG. The G allele of LPL was si gnificantly associated with low TG levels. We found a clear interactio n between the LPL/apoE polymorphisms and apoE levels on serum TG varia tion. Total variability of TG levels in women and men of 42.31% and 53 .62% respectively, were mainly explained by apoE concentration and the se two polymorphisms. ApoE and LPL genes simultaneously modulated TG l evels.