Fluorescence molecular sensing for endocrine-disrupting chemicals and their analogues based on dansyl or anthranilate modified beta- and gamma-cyclodextrins
M. Narita et al., Fluorescence molecular sensing for endocrine-disrupting chemicals and their analogues based on dansyl or anthranilate modified beta- and gamma-cyclodextrins, ANAL SCI, 16(1), 2000, pp. 37-43
A fluorescent chemo-sensor for endocrine-disrupting chemicals has been stud
ied by investigating fluorescence spectral changes with and without a guest
molecule of regio-selective bis dansylglycine or anthranilate modified bet
a-and gamma-cyclodextrins. These host compounds show an increasing or decre
asing pure monomer fluorescence intensity upon the addition of such guests
as dioxin analogues, p-nonylphenol, 2,4-dichlorophenoxyacetic acid, bisphen
ol A, and diethyl phthalate. The extent of the fluorescence variations with
the guest is used to display the sensing factors, Delta I/I-o, of these ho
st molecules, where I and I-o are the fluorescence intensities in the prese
nce and absence of a guest and Delta I is I-I-o. These hosts exhibit variou
s values of Delta I/I-o, which indicates the possibility of pattern recogni
tion for endocrine-disrupting chemicals. These guests are detected with a r
emarkable response range by these hosts.