Fluorescence molecular sensing for endocrine-disrupting chemicals and their analogues based on dansyl or anthranilate modified beta- and gamma-cyclodextrins

A fluorescent chemo-sensor for endocrine-disrupting chemicals has been stud ied by investigating fluorescence spectral changes with and without a guest molecule of regio-selective bis dansylglycine or anthranilate modified bet a-and gamma-cyclodextrins. These host compounds show an increasing or decre asing pure monomer fluorescence intensity upon the addition of such guests as dioxin analogues, p-nonylphenol, 2,4-dichlorophenoxyacetic acid, bisphen ol A, and diethyl phthalate. The extent of the fluorescence variations with the guest is used to display the sensing factors, Delta I/I-o, of these ho st molecules, where I and I-o are the fluorescence intensities in the prese nce and absence of a guest and Delta I is I-I-o. These hosts exhibit variou s values of Delta I/I-o, which indicates the possibility of pattern recogni tion for endocrine-disrupting chemicals. These guests are detected with a r emarkable response range by these hosts.