Influence of a nasal spray consisting of standardized composition of Citrus limon (succus) and an aqueous extract form Cydonia oblonga (fructus) on the intranasal mucociliary clearance
J. Degen et al., Influence of a nasal spray consisting of standardized composition of Citrus limon (succus) and an aqueous extract form Cydonia oblonga (fructus) on the intranasal mucociliary clearance, ARZNEI-FOR, 50(1), 2000, pp. 39-42
In a three-way-crossover study in 18 healthy male and female subjects aged
from 20 to 49 years the influence of a 1 % and 3 % solution of a standardiz
ed composition of Citrus limon, succus, and extract from Cydonia oblonga, f
ructus (Gencydo(R)) on the intranasal mucociliar clearance was investigated
after multiple administration. The pH of the solution was about pH 2.3-3.2
. The dose regimen consisted of 20 puffs (0.13 mi per puff) in each nostril
within 24 h, which was by factor 3-10 higher than the usual therapeutic do
sage of 2-6 puffs per nostril and 24 h. The mucociliar transport time tt as
measured by a modified saccharin test, where 1 mu l of a 3-molar aqueous s
odium saccharinate solution was applicated at the inferior nasal turbinate
cm from its anterior end using a glass capillary microliter pipet. This tes
t was performed at screening examination, before each administration period
, directly after each 24 h treatment period and 24 h after the end of each
treatment. The time of initial taste perception could be defined with high
precision by the volunteer since it appeared very spontaneously. Neither af
ter intranasal administration of the 1 % and 3 % Citrus/Cydonia solution no
r after placebo solution a prolongation of the perception time was found. I
t could be concluded that there is no measurable influence of the test prod
ucts on the intranasal ciliar function.