Individual crewmember escape from a disabled U.S. Navy nuclear submarine ha
s never been necessary, but remains an important contingency. Decompression
sickness (DCS) is one of the foreseeable risks and a robust mathematical m
odel of DCS incidence has been used to estimate the magnitude of this risk
under a variety of escape scenarios. The model was calibrated with over 300
0 well-controlled human pressure exposures, less than 2% of which simulated
pressure profiles of submarine escape. For disabled submarine depths <300
ft of sea water (fsw) and internal submarine pressures of <11 fsw (arguably
the most likely conditions), the DCS risks are comparable to those routine
ly undertaken by U.S. Navy divers-less than 5%. For progressively deeper de
pths and especially for higher submarine internal pressures, the risk of DC
S becomes much greater, including unknown chances of permanent injury and d
eath. Variations from the baseline escape procedure are explored, including
equipment differences, delays in exiting the submarine and changes in the
oxygen content of the breathing mix.