The relations among consciousness, brain, behavior, and scientific explanat
ion are explored in the domain of color perception. Current scientific know
ledge about color similarity;, color composition, dimensional structure, un
ique colors, and color categories is used to assess Locke's "inverted spect
rum argument" about the undetectability of color transformations. A symmetr
y analysis of color space shows that the literal interpretation of this arg
ument - reversing the experience of a rainbow - would not work. Three other
color-to-color transformations might work, however, depending on the relev
ance of certain color categories. The approach is then generalized to exami
ne behavioral detection of arbitrary differences in color experiences, lead
ing to the formulation of a principled distinction, called the "isomorphism
constraint," between what can and cannot be determined about the nature of
color experience by objective behavioral means. Finally, the prospects for
achieving a biologically based explanation of color experience below the l
evel of isomorphism are considered in light of the limitations of behaviora
l methods. Within-subject designs using biological interventions hold the g
reatest promise for scientific progress on consciousness, but objective kno
wledge of another person's experience appears impossible. The implications
of these arguments for functionalism are discussed.