K. Sjogren et al., Disproportional skeletal growth and markedly decreased bone mineral content in growth hormone receptor -/- mice, BIOC BIOP R, 267(2), 2000, pp. 603-608
Citations number
33
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Growth hormone (GH) is important for skeletal growth as well as for a norma
l bone metabolism in adults. The skeletal growth and adult bone metabolism
was studied in mice with an inactivated growth hormone receptor (GHR) gene,
The lengths of femur, tibia, and crown-rump were, as expected, decreased i
n GHR-/- mice. Unexpectedly, GHR-/- mice displayed disproportional skeletal
growth reflected by decreased femur/crown-rump and femur/tibia ratios. GHR
-/- mice demonstrated decreased width of the growth plates in the long bone
s and disturbed ossification of the proximal tibial epiphysis. Furthermore,
the area bone mineral density (BMD) as well as the bone mineral content (B
MC)/body weight were markedly decreased in GHR-/- mice. The decrease in BMC
in GHR-/- mice was not due to decreased trabecular volumetric BMD but to a
decreased cross-sectional cortical bone area In conclusion, GHR-/- mice de
monstrate disproportional skeletal growth and markedly decreased bone miner
al content, (C) 2000 academic Press.