Epicubenol synthase. Origin of the oxygen atom of a bacterial sesquiterpene alcohol

Authors
Cane, DE Ke, N
Citation
De. Cane et N. Ke, Epicubenol synthase. Origin of the oxygen atom of a bacterial sesquiterpene alcohol, BIOORG MED, 10(2), 2000, pp. 105-107
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
2
Year of publication
2000
Pages
105 - 107
Database
ISI
SICI code
0960-894X(20000117)10:2<105:ESOOTO>2.0.ZU;2-S
Abstract
Incubation of epicubenol synthase with farnesyl pyrophosphate in the presen ce of 11.1 atom% (H2O)-O-18 gave epicubenol (2) in which the hydroxyl oxyge n atom was shown to be derived exclusively from water, as established by GC -selected ion monitoring MS of the derived TMS-epicubenol derivative (15). (C) 2000 Elsevier Science Ltd. All rights reserved.