Structure-activity relationships of trans-3,5-disubstituted pyrrolidinylthio-1 beta-methylcarbapenems. Part 1: J-111,347 and related compounds

Authors
Imamura, H Ohtake, N Shimizu, A Jona, H Sato, H Nagano, R Ushijima, R Yamada, K Hashizume, T Morishima, H
Citation
H. Imamura et al., Structure-activity relationships of trans-3,5-disubstituted pyrrolidinylthio-1 beta-methylcarbapenems. Part 1: J-111,347 and related compounds, BIOORG MED, 10(2), 2000, pp. 109-113
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
2
Year of publication
2000
Pages
109 - 113
Database
ISI
SICI code
0960-894X(20000117)10:2<109:SROTP>2.0.ZU;2-#
Abstract
1 beta-Methylcarbapenems having various 3,5-disubstituted pyrrolidinylthio- side chains at C-2 were designed and synthesized. Evaluation of their antib acterial activities indicated that J-111,347 (la) is the first example of a n extremely broad spectrum antibiotic showing activity against methicillin- resistant Staphylococcus aureus (MRSA) as well as Pseudomonas aeruginosa. ( C) 2000 Elsevier Science Ltd. All rights reserved.