Structure-activity relationship study of asiatic acid derivatives against beta amyloid (A beta)-induced neurotoxicity

Authors
Jew, SS Yoo, CH Lim, DY Kim, H Mook-Jung, I Jung, MW Choi, H Jung, YH Kim, H Park, HG
Citation
Ss. Jew et al., Structure-activity relationship study of asiatic acid derivatives against beta amyloid (A beta)-induced neurotoxicity, BIOORG MED, 10(2), 2000, pp. 119-121
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
2
Year of publication
2000
Pages
119 - 121
Database
ISI
SICI code
0960-894X(20000117)10:2<119:SRSOAA>2.0.ZU;2-U
Abstract
8 Semi-synthetic derivatives of asiatic acid were prepared and their protec tive effect against AP-induced neurotoxicity was evaluated. Among them, asi atic acid (2), and 4, 16 showed 97, 92 and 87% of protective effect, respec tively. (C) 2000 Elsevier Science Ltd. All rights reserved.