Benzoangelicins 4-6 were synthesized in good yields from 7-hydroxy-5-methox
y-4-methylcoumarin (1). In the absence of UVA radiation, compounds 5 and 6
were only weakly active against HL60 and HeLa tumour cells; in its presence
, compound 6 was 10 times more active than the reference compound 8-methoxy
psoralen. None of 4-6 exhibited cutaneous phototoxicity. (C) 2000 Elsevier
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