A new benzoangelicin with strong photobiological activity

Authors
Santana, L Uriarte, E Dalla Via, L Gia, O
Citation
L. Santana et al., A new benzoangelicin with strong photobiological activity, BIOORG MED, 10(2), 2000, pp. 135-137
Citations number
16
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
2
Year of publication
2000
Pages
135 - 137
Database
ISI
SICI code
0960-894X(20000117)10:2<135:ANBWSP>2.0.ZU;2-P
Abstract
Benzoangelicins 4-6 were synthesized in good yields from 7-hydroxy-5-methox y-4-methylcoumarin (1). In the absence of UVA radiation, compounds 5 and 6 were only weakly active against HL60 and HeLa tumour cells; in its presence , compound 6 was 10 times more active than the reference compound 8-methoxy psoralen. None of 4-6 exhibited cutaneous phototoxicity. (C) 2000 Elsevier Science Ltd. All rights reserved.