Synthesis of ketomethylene amino pseudopeptide analogues via reductive amination of glyoxals derived from alpha-amino acids

Authors
Groarke, M Hartzoulakis, B McKervey, MA Walker, B Williams, CH
Citation
M. Groarke et al., Synthesis of ketomethylene amino pseudopeptide analogues via reductive amination of glyoxals derived from alpha-amino acids, BIOORG MED, 10(2), 2000, pp. 153-155
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
2
Year of publication
2000
Pages
153 - 155
Database
ISI
SICI code
0960-894X(20000117)10:2<153:SOKAPA>2.0.ZU;2-V
Abstract
The reductive amination of an amino acid derived glyoxal, with the free ami no group of a protected amino acid or oligopeptide fragment, has been devel oped as a simple and efficient method for the preparation of ketomethylene amino pseudo-oligopeptide isosteres Aa psi(COCH2NH)Aa. Trichlorosilane-DMF is the reagent of choice for the reduction. (C) 2000 Elsevier Science Ltd. All rights reserved.