The use of power ultrasound coupled with magnetic separation for the solidphase synthesis of compound libraries

Authors
Perez, JM Wilhelm, EJ Sucholeiki, I
Citation
Jm. Perez et al., The use of power ultrasound coupled with magnetic separation for the solidphase synthesis of compound libraries, BIOORG MED, 10(2), 2000, pp. 171-174
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
2
Year of publication
2000
Pages
171 - 174
Database
ISI
SICI code
0960-894X(20000117)10:2<171:TUOPUC>2.0.ZU;2-M
Abstract
Enhanced reaction rates are observed when power ultrasound is utilized as a substitute for mixing during solid phase organic chemical reactions on a p aramagnetic support. Power ultrasound is also used to facilitate the washin g of the paramagnetic support as it is magnetically separated from the reac tion mixture. Selective examples from a library targeting the kappa-opioid receptor are presented. (C) 2000 Elsevier Science Ltd. All rights reserved.