RGD mimetics containing a central hydantoin scaffold: alpha(v)beta(3) vs alpha(IIb)beta(3) selectivity requirements

Authors
Peyman, A Wehner, V Knolle, J Stilz, HU Breipohl, G Scheunemann, KH Carniato, D Ruxer, JM Gourvest, JF Gadek, TR Bodary, S
Citation
A. Peyman et al., RGD mimetics containing a central hydantoin scaffold: alpha(v)beta(3) vs alpha(IIb)beta(3) selectivity requirements, BIOORG MED, 10(2), 2000, pp. 179-182
Citations number
24
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
2
Year of publication
2000
Pages
179 - 182
Database
ISI
SICI code
0960-894X(20000117)10:2<179:RMCACH>2.0.ZU;2-Q
Abstract
The synthesis of a series of RGD mimetic alpha(v)beta(3) antagonists contai ning a hydantoin scaffold is shown. The results demonstrate some of the str uctural requirements for the design of selective alpha(v)beta(3) antagonist s (vs alpha(11b)beta(3)) in terms of the Arg-mimetic, the distance between N- and C-terminus and the lipophilic side chain. (C) 2000 Elsevier Science Ltd. All rights reserved.