Resin effects in solid phase SNAr and S(N)2 macrocyclizations

Seven different supports were compared in solid-phase SNAr and S(N)2 macroc yclization reactions. Product purities were assayed for a relatively facile ring-closure process to give products 1 and 3. Some less-facile ring-closu re reactions give the undesired dimeric macrocyclization by-products 2; som e of these more-demanding ring closures were also examined. Finally, experi ments were performed to gauge the rate of cyclizations on different resins, and some qualitative data were obtained for this. (C) 2000 John Wiley & So ns, Inc.