Streamlined synthesis of substituted 2-aminothiazoles using tandem precipitative and polymer-assisted reactions

The tactical combination of classical product precipitation and subsequent modification of precipitated products using polymer-assisted transformation s has been employed in the preparation of substituted 2-aminothiazole deriv atives. 2-aminothiazoles were precipitated in parallel as hydrobromide mono hydrate salts, directly redissolved, and reacted further using polymer-supp orted reagents to afford free-based 2-aminothiazoles, aminothiazoyloxamates , and aminothiazoylamides. (C) 2000 John Wiley & Sons, Inc.