Analysis of the insertion/deletion polymorphism of the human angiotensin converting enzyme (ACE) gene in patients with renal cancer

Authors
Usmani, BA Janeczko, M Shen, R Mazumdar, M Papandreou, CN Nanus, DM
Citation
Ba. Usmani et al., Analysis of the insertion/deletion polymorphism of the human angiotensin converting enzyme (ACE) gene in patients with renal cancer, BR J CANC, 82(3), 2000, pp. 550-552
Citations number
21
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
BRITISH JOURNAL OF CANCER
ISSN journal
00070920 → ACNP
Volume
82
Issue
3
Year of publication
2000
Pages
550 - 552
Database
ISI
SICI code
0007-0920(200002)82:3<550:AOTIPO>2.0.ZU;2-6
Abstract
The angiotensin I-converting enzyme (ACE) contains an insertion/deletion (l /D) polymorphism, with the DD genotype associated with benign renal disease s. The distribution frequencies of the D and I alleles, and the DD, DI and II genotypes were determined in DNA extracted from kidney tissues of 58 ren al cancer patients. The observed frequencies in patients who develop renal cancer was not significantly different than the normal population. (C) 2000 Cancer Research Campaign.