Low molecular weight heparin; a novel alternative therapeutic approach forlichen planus

Heparin analogues in low doses have antiproliferative and immunomodulatory properties. The aim of this study was to evaluate the effect of low-dose en oxaparin administered subcutaneously in lichen planus (LP). Eighteen patien ts with various types of LP were treated in an open study for 6-13 weeks. E fficacy and safety data were recorded, Complete remission was observed in 1 1 of 18 patients (61%) and marked improvement in two (11%). Widespread cuta neous involvement and reticulated oral LP had the best response, while in L P of the scalp the response was poor. Enoxaparin is a promising alternative therapy for various types of LF.