Ceftriaxone therapy for staphylococcal osteomyelitis: A review

Ceftriaxone, although less active than standard antistaphylococcal agents, is potentially useful in the treatment of osteomyelitis, Thirty-one patient s with osteomyelitis due to Staphylococcus aureus were identified, 22 of wh om were treated with ceftriaxone and 9 with other agents. Of those patients treated with ceftriaxone, 17 were cured; all treatment failures were assoc iated with chronic osteomyelitis and continued presence of necrotic bone or infected hardware. It is concluded that ceftriaxone is effective in the am bulatory treatment of S, aureus osteomyelitis.