Dysfunction of small myelinated afferents in diabetic polyneuropathy, as assessed by laser evoked potentials

Objective: To verify whether laser evoked potentials are useful in assessin g the function of small afferent fibers and to compare dysfunction of large and small afferent fibers in patients with diabetic polyneuropathy. Methods: The brain potentials evoked by CO2 laser stimulation of the hand a nd foot were studied in diabetic patients (n = 45) with various degrees of peripheral nerve damage. Laser evoked potentials (which assess the function of small myelinated afferents) were also compared with ulnar and sural ner ve sensory action potentials (which assess the function of large myelinated afferents) by scoring the abnormalities of the two neurophysiological test s with similar criteria. Results: Laser evoked potentials were often absent: the mean latency was no rmal and mean amplitude decreased, as expected in axonopathies. Although cl inical examination showed more frequent impairment of vibratory than pinpri ck sensation, laser evoked potentials and sensory action potentials yielded similar abnormality scores and showed a strong intra-individual correlatio n. Conclusions: Laser evoked potentials, possibly better than standard clinica l examination for assessing the abnormalities of small-diameter afferents, indicate that diabetic polyneuropathy induces large- and small-afferent dys function in parallel. (C) 2000 Published by Elsevier Science ireland Ltd. A ll rights reserved.