A variety of management errors, nutritional problems, and infectious diseas
es may result in weight loss in sheep. When initiating an investigation of
weight loss in a single sheep or a flock, practitioners may become frustrat
ed when confronted with the wide range of diagnostic differentials. This ar
ticle describes important considerations for diagnostic investigation of ov
ine weight loss and briefly reviews the differential diagnosis for this pro
blem. Emphasis is placed on diagnostic testing, treatment, and prevention o
r control.