Objectives: To describe the clinical manifestations of viral hemorrhagic fe
ver, and to increase clinicians' awareness and knowledge of these illnesses
.
Design: Retrospective study of the clinical and laboratory data and managem
ent of two cases of Ebola virus infection with key epidemiologic data provi
ded.
Setting: Two tertiary care hospitals,
Patients: Two adult patients, the index case and the source patient, both i
dentified as having Ebola, one of whom originated in Gabon.
Interventions: One patient was admitted to the intensive care unit, The oth
er was managed in a general ward.
Measurement and Main Results: Clinical and laboratory data are reported. On
e patient, a healthcare worker who contracted this illness in the course of
her work, died of refractory thrombocytopenia and an intracerebral bleed.
The source patient survived. Despite a long period during which the diagnos
is was obscure, none of the other 300 contacts contracted the illness.
Conclusions: Identification of high-risk patients and use of universal bloo
d and body fluid precautions will considerably decrease the risk of nosocom
ial spread of viral hemorrhagic fevers.